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Semaglutide and liraglutide are drugs that were developed to treat diabetes and are FDA-approved for that. They are given by subcutaneous injection. Semaglutide is also FDA-approved for weight loss in non-diabetics if certain conditions are met. Once-weekly semaglutide outperformed daily liraglutide in overweight and obese non-diabetics. From. Other GLP-1 RAs for Diabetes That Also Help with Weight Loss: Trulicity (dulaglutide) is a once-weekly injection dosed at 0.75mg, 1.5mg, 3.0mg, or 4.5mg. ... The STEP 2 clinical trial looked at the impact of semaglutide on weight reduction in people with type 2 diabetes over a 68-week period. The trial found that semaglutide at a 1.0mg dose was. In the weight loss clinical trials, patients without type 2 diabetes experienced episodes of hypoglycemia. Local. Common (1% to 10%): Injection site reactions. Immunologic. Frequency not reported: Development of anti-semaglutide antibodies. As with other protein and peptide pharmaceuticals, patients receiving this drug have developed anti.
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